| I 25 | Southeast | | the Colorado State Line | Cheyenne |
| I 80 | Southeast | | Archer Interchange | WY 217 |
| I 25 | Southeast | | Laramie County Line | WY 321 |
| US 287 | Southeast | | the Colorado State Line | Start of Divided Highway, Mile Marker 416 |
| WY 10 | Southeast | | Woods Landing | the Colorado State Line |
| WY 11 | Southeast | | WY 130 | Albany |
| WY 12 | Southeast | | WY 130 | Mandel Lane |
| WY 130 | Southeast | | I-80, Walcott Jct | WY 230 |
| WY 13 | Southeast | | Rock River | Arlington |
| WY 211 | Southeast | | WY 219, Yellowstone Rd | Jordan Road |
| WY 213 | Southeast | | I-80 | US 85 |
| WY 216 | Southeast | | US 85 | the Nebraska State Line |
| WY 225 | Southeast | | I-80, Otto Rd | Cheyenne |
| WY 230 | Southeast | | WY 130 | Riverside |
| WY 270 | Southeast | | Guernsey | the Niobrara/Platte Cty Line |
| WY 313 | Southeast | | Chugwater | US 85 |
| WY 320 | Southeast | | Wheatland | Grey Rocks Closure Gate |
| WY 321 | Southeast | | Chugwater | I-25 |
| WY 34 | Southeast | | Bosler | Morton Pass |
| WY 72 | Southeast | | I-80 | Hanna Jct |
| WY 77 | Southeast | | the South Jct WY 487 | Mile Marker 132, Northbound Closure Gate |
| I 25 | Southeast | | Cheyenne | Exit 29, Whitaker Rd |
| US 18 | Southeast | | Lost Springs | Lusk |
| US 287 | Southeast | | Start of Divided Highway, Mile Marker 416 | Mile Marker 413, 4 Miles North of Tie Siding |
| US 85 | Southeast | | Cheyenne | Meriden |
| WY 130 | Southeast | | WY 230 | Mile Marker 48, Eastbound Closure Gate |
| WY 210 | Southeast | | Mile Marker 16, County Rd 109, Table Mtn Rd | Curt Gowdy State Park |
| WY 230 | Southeast | | Riverside | the Colorado State Line |
| WY 270 | Southeast | | the Niobrara/Platte Cty Line | Manville |
| WY 320 | Southeast | | Grey Rocks Closure Gate | US 26 |
| WY 34 | Southeast | | Morton Pass | the Platte/Albany County Line |
| WY 487 | Southeast | | the South Jct WY 77 | the North Jct WY 77 |
| WY 77 | Southeast | | Mile Marker 132, Northbound Closure Gate | Mile Marker 142, Southbound Closure Gate |
| I 25 | Southeast | | Exit 29, Whitaker Rd | Chugwater |
| US 287 | Southeast | | Mile Marker 413, 4 miles north of Tie Siding | Laramie |
| US 85 | Southeast | | Meriden | WY 151, Bear Mountain Station |
| WY 210 | Southeast | | Curt Gowdy State Park | I-80 |
| WY 270 | Southeast | | Manville | US 18/85 |
| WY 34 | Southeast | | the Platte/Albany Cty Line | Tally Ho Ranch |
| WY 487 | Southeast | | the North Jct WY 77 | WY 220 |
| WY 77 | Southeast | | Mile Marker 142, Southbound Closure Gate | the North Jct WY 487 |
| I 25 | Southeast | | Chugwater | Exit 73, WY 34 |
| US 85 | Southeast | | WY 151, Bear Mountain Station | WY 161, Silvertip |
| WY 230 | Southeast | | Woods Landing | Laramie |
| WY 34 | Southeast | | Tally Ho Ranch | I-25 |
| I 25 | Southeast | | Exit 73, WY 34 | Wheatland |
| US 85 | Southeast | | WY 161, Silvertip | Torrington |
| WY 70 | Southeast | | Mile Marker 50, Westbound Closure Gate | WY 230 |
| I 25 | Southeast | | Wheatland | Exit 92, US 26 |
| US 85 | Southeast | | Torrington | Lingle |
| WY 130 | Southeast | | Centennial | WY 130/230 |
| US 85 | Southeast | | Lingle | Jay Em |
| US 85 | Southeast | | Jay Em | Lusk |
| US 85 | Southeast | | Lusk | Mule Creek Jct |
| US 287 | Southeast | | Rawlins | Mile Marker 23 |
| I 80 | Southeast | | Exit 187, Creston Jct | Rawlins |
| I 80 | Southeast | | Rawlins | Exit 235, Walcott Jct |
| I 80 | Southeast | | Exit 235, Walcott Jct | Exit 255, WY 72 |
| US 30 | Southeast | | I-80, Walcott Jct | Hanna Jct |
| I 80 | Southeast | | Exit 255, WY 72 | Exit 267, Wagonhound Rd |
| US 30 | Southeast | | Hanna Jct | Medicine Bow |
| I 80 | Southeast | | Exit 267, Wagonhound Rd | Arlington |
| US 30 | Southeast | | Medicine Bow | Rock River |
| I 80 | Southeast | | Arlington | Exit 279, Cooper Cove Rd |
| US 30 | Southeast | | Rock River | Divided Highway at Mile Marker 290 |
| I 80 | Southeast | | Exit 279, Cooper Cove Rd | Exit 290, Quealy Dome |
| US 30 | Southeast | | Divided Highway at Mile Marker 290 | Divided Highway at Mile Marker 308 |
| I 80 | Southeast | | Exit 290, Quealy Dome | Laramie |
| US 20 | Southeast | | Lusk | the Nebraska State Line |
| US 26 | Southeast | | I-25, Dwyer Jct | Guernsey |
| US 30 | Southeast | | Divided Highway at Mile Marker 308 | WY 34, Closure Gate |
| I 80 | Southeast | | Laramie | Exit 323, Happy Jack Rd |
| US 26 | Southeast | | Guernsey | Lingle |
| US 30 | Southeast | | WY 34, Closure Gate | Laramie |
| I 80 | Southeast | | Exit 323, Happy Jack Rd | Exit 335, Buford |
| I 80 | Southeast | | Exit 335, Buford | Exit 348, Otto Rd |
| US 26 | Southeast | | Torrington | the Nebraska State Line |
| I 80 | Southeast | | Exit 348, Otto Rd | Exit 359, Junction I-25 |
| I 80 | Southeast | | Exit 359, Junction I-25 | Exit 364, College Drive |
| I 80 | Southeast | | Exit 364, College Drive | Exit 370, Archer Interchange |
| I 80 | Southeast | | Exit 370, Archer Interchange | Exit 377, WY 217 |
| I 80 | Southeast | | Exit 377, WY 217 | Pine Bluffs |
| I 80 | Southeast | | Pine Bluffs | the Nebraska State Line |